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UID:20250512T193007EDT-3388Zxun4B@132.216.98.100
DTSTAMP:20250512T233007Z
DESCRIPTION:Causes and Consequences of Plasticity in Cancer and Development
 \n\nDana Pe'er\, Memorial Sloan Kettering Cancer Center\n	Tuesday November 
 9\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/85428056343\n\nAbstract: C
 ellular plasticity\, the ability to take on unexpected fates or identities
 \, is a fundamental property of multicellular life that enables coordinati
 on during development and wound healing. A number of diseases lead to grea
 tly enhanced plasticity\, with cancer perhaps foremost among these. We sho
 w how high-resolution single-cell approaches such as transcriptome and chr
 omatin accessibility profiling can be exploited to understand the causes a
 nd consequences of cellular plasticity. Using analytical approaches that w
 e developed to identify cellular trajectories and cell-state transitions a
 nd to quantify cell fate potential from this data\, we reveal striking pla
 sticity in the context of early endodermal development in the mouse. We de
 scribe a number of approaches for quantifying plasticity\, and demonstrate
  how both oncogenic mutation and environmental insults can lead to dramati
 c increases in tumor cell plasticity. Our work provides insights into puta
 tive regulatory mechanisms underlying these phenotypic expansions\, and re
 veals how cancer cells can inappropriately gain access to diverse developm
 ental programs that allow them to colonize new anatomical sites during met
 astasis. Over and over\, we observe that cancer cells use developmental pl
 asticity as an adaptive mechanism for dealing with new environments and dr
 iving malignant progression.\n
DTSTART:20211109T170000Z
DTEND:20211109T180000Z
LOCATION:CA\, QC
SUMMARY:QLS Seminar Series - Dana Pe'er
URL:/qls/channels/event/qls-seminar-series-dana-peer-3
 34412
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