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UID:20250513T114644EDT-0157akJu2U@132.216.98.100
DTSTAMP:20250513T154644Z
DESCRIPTION:Modeling axon-myelin relationships: insights on signal propagat
 ion and modulation\n\nClaire Guerrier\, Université Côte d'Azur\n	Tuesday Fe
 bruary 18\, 12-1pm\n	Montreal Neurological Institute\, deGrandpre Communica
 tions Centre\n\nAbstract: The profound functional significance of myelin i
 s revealed by the severe neurological deficits that are consequent upon mu
 ltiple inherited or acquired demyelinating conditions. Recent observations
  demonstrate that the dimensions of myelin sheaths relative to axon calibr
 es can be modulated in response to adult experience with significant funct
 ional consequences. Despite the widely accepted demonstration that adult m
 yelin is adaptive and the rapidly growing evidence that such plasticity pl
 ays a key role in both normal and abnormal nervous system function\, the e
 ffects of such myelin and axonal organization changes on signal propagatio
 n are not clearly understood.\n	In this project\, using data on myelin shea
 th thickness in relation to axonal diameter coming from gene edited mice\,
  we investigate the effects of myelination on the propagation of electrica
 l signals along these axons and vice versa. We consider an electrical mode
 l based on cable theory and on Holdgkin-Huxley type formalism to represent
  voltage gated channels at the nodes of Ranvier (NoR).\n	Using this model\,
  we investigate the effects of parameter sets corresponding to pathologica
 l myelin-axon-NoR organisation\, on signal propagation. Using mathematical
  analysis and simulations\, we show that the different frequencies constit
 uting a signal travel at their own speed\, that depends on the fibre prope
 rties. Although in normal axons and for a typical signal\, the difference 
 of speed for different frequencies is negligible\, in abnormal demyelinate
 d axons\, there are drastic differences\, which perturbs signal propagatio
 n and modifies the shape of the outcoming signal.\n\n \n
DTSTART:20200218T170000Z
DTEND:20200218T180000Z
LOCATION:deGrandpre Communications Centre\, Montreal Neurological Institute
 \, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:QLS Seminar - Claire Guerrier
URL:/qls/channels/event/qls-seminar-claire-guerrier-31
 9670
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