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UID:20250515T122555EDT-44282dmS12@132.216.98.100
DTSTAMP:20250515T162555Z
DESCRIPTION:How adaptive immunity constrains the composition and fate of la
 rge bacterial populations\n\nSidartha Goyal (University of Toronto)\n	Tuesd
 ay February 26\, 12-1pm\n	deGrandpre Communication Centre\, Montreal Neurol
 ogical Institute\n	\n	Abstract: Bacteria learn from past viral attacks by in
 tegrating small segments of viral genomes (spacers) into their DNA to neut
 ralize future attacks. This memory of past attacks is then inherited along
  a bacterium’s lineage suggesting its effect on the fate and structure of 
 the whole microbial population. Emphasizing the population-level impact of
  the adaptive immunity\, recent experiments show that some bacteria regula
 te adaptive-immunity-associated genes via the quorum-sensing (QS) pathway.
  I will present a model that shows how from the highly stochastic dynamics
  of individual spacers emerges a rank-abundance distribution of spacers th
 at is time invariant\, a surprising prediction that is consistent with dyn
 amic spacer-tracking data in experiments. This distribution depends on the
  state of the competing virus–bacteria population\, which due to QS-based 
 control exhibits multiple stable states with drastically different virus-b
 acterium composition.\n
DTSTART:20190226T170000Z
DTEND:20190226T180000Z
LOCATION:deGrandpre Communications Centre\, Montreal Neurological Institute
 \, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Seminar Series in Quantitative Life Sciences and Medicine
URL:/qls/channels/event/seminar-series-quantitative-li
 fe-sciences-and-medicine-293904
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