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UID:20250513T114726EDT-9832Mr4D2U@132.216.98.100
DTSTAMP:20250513T154726Z
DESCRIPTION:'The interplay of structural and cellular biophysics controls c
 lustering of multivalent molecules'\n\nLeslie Loew (University of Connecti
 cut)\n	Tuesday November 6\, 12-1pm\n	McIntyre Building\, Room 1027\n	\n	Abstra
 ct: Dynamic molecular clusters are assembled through weak multivalent inte
 ractions and are platforms for cellular functions\, especially receptor-me
 diated signaling. Using coarse-grain kinetic Langevin dynamics\, we perfor
 med computational experiments on a prototypical ternary system modeled aft
 er membrane-bound nephrin\, the adaptor Nck1 and the actin nucleation prom
 oting factor NWASP. Steady state cluster size distributions favored stoich
 iometries that optimized binding\, but still were quite broad. A balance o
 f enthalpy and entropy limited the number of molecules per cluster\, with 
 complete annealing into a single complex being exceedingly rare. Domains c
 lose to binding sites sterically inhibited clustering much less than termi
 nal domains because the latter effectively restrict access to the cluster 
 interior. Increased flexibility of interacting molecules diminished cluste
 ring by shielding binding sites within compact conformations. Membrane ass
 ociation of nephrin increased the cluster size distribution in a density-d
 ependent manner. These properties provide insights into how molecular ense
 mbles function to localize and amplify cell signaling.\n
DTSTART:20181106T170000Z
DTEND:20181106T180000Z
LOCATION:Room 1027\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar Series in Quantitative Life Sciences and Medicine
URL:/qls/channels/event/seminar-series-quantitative-li
 fe-sciences-and-medicine-290631
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