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UID:20250726T204618EDT-4575vRKnRe@132.216.98.100
DTSTAMP:20250727T004618Z
DESCRIPTION:\n	Mechanosensitive ion channels rely on membrane composition to
  transduce physical stimuli into electrical signals. The Piezo1 channel me
 diates mechanoelectrical transduction and regulates crucial physiological 
 processes\, including vascular architecture and remodeling\, cell migratio
 n\, and erythrocyte volume. Whereas Piezo2 is essential for touch discrimi
 nation\, vibration\, and proprioception. The identity of the membrane comp
 onents that modulate Piezo channels function remain largely unknown. Using
  lipid profiling analyses\, we identified dietary fatty acids that tune Pi
 ezo channels mechanical response. We found that margaric acid\, a saturate
 d fatty acid present in dairy products and fish\, inhibits Piezo1 and Piez
 o2 activation and polyunsaturated fatty acids (PUFAs)\, present in fish oi
 ls\, modulate Piezo1 inactivation. Using atomic force microscopy\, we reve
 aled that margaric acid increases membrane bending stiffness\, whereas PUF
 As decrease it. We use PUFA supplementation to abrogate the phenotype of g
 ain-of-function Piezo1 mutations (causing hemolytic anemia)\, and margaric
  acid to counteract PIEZO2 sensitization by the proalgesic agent bradykini
 n. Beyond Piezo channels\, our findings demonstrate that cell-intrinsic li
 pid profile and changes in the fatty acid metabolism can dictate the cell'
 s response to mechanical cues.\n\nThis seminar will take place both in-per
 son and online. Details in attached poster.\n
DTSTART:20220527T150000Z
DTEND:20220527T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar: Dietary fatty acids fine-tune neuronal and non-neuronal ce
 lls mechanical response
URL:/physiology/channels/event/seminar-dietary-fatty-a
 cids-fine-tune-neuronal-and-non-neuronal-cells-mechanical-response-337703
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