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UID:20250722T094406EDT-8840Oi6CBH@132.216.98.100
DTSTAMP:20250722T134406Z
DESCRIPTION:The development of a single fertilised cell into an embryo is a
  highly dynamic process that establishes the structural and functional arc
 hitecture of the organism. The building of complex multicellular structure
 s fundamentally emerges from the spatio-temporal coordination of dynamic b
 ehaviours at the single cell level. How this multi-scale process occurs wi
 th high fidelity and robustness is still a major open question. In order t
 o establish and maintain proper tissue form and function\, single cells ne
 ed to precisely decode mechano-chemical information in their microenvironm
 ent and adaptively respond to these signals under normal and stress condit
 ions.\n\nHere I will first discuss how embryonic stem cells are able to se
 nse mechanical shape deformations and physical confinement in their 3D tis
 sue environment. I will explore the function of the cell nucleus as an int
 racellular mechano-sensor and how it can function as a non-genetic control
 ler of dynamic cell behaviour and migration plasticity. I will finally dis
 cuss how developmental robustness and error correction are established by 
 mechanical cell cooperation that facilitates phagocytic tissue clearance o
 f aberrant apoptotic cells in the earliest stages of embryo development.\n
 \nThis seminar will be given online via Zoom. Details in attached poster.
 \n
DTSTART:20220311T160000Z
DTEND:20220311T170000Z
SUMMARY:Online seminar: Mechanical forces as regulators of single cell dyna
 mics and tissue function during early development
URL:/physiology/channels/event/online-seminar-mechanic
 al-forces-regulators-single-cell-dynamics-and-tissue-function-during-early
 -337487
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