Maiya R. Geddes, MD, FRCPC
Dr. Geddes is an FRSQ neurologist scientist and an Associate Professor in the Department of Neurology and Neurosurgery at 秀色直播. She听directs a research program at The Neuro within the Cognitive Neuroscience Unit and Brain Imaging Centre that focuses on motivational neuromedicine in aging. The goal of this highly translational program is to understand the neurobiological听mechanisms underlying motivational resilience and vulnerability in human aging and Alzheimer鈥檚 disease with the goal of helping older adults lead healthier and more fulfilling lives. 听Dr. Geddes鈥� research combines cutting-edge behavioural and multi-modal neuroimaging techniques including task-based and resting-state functional magnetic resonance imaging (fMRI). To translate her research findings, Dr. Geddes designs and leads novel intervention trials to enhance adherence to protective behaviours with the ultimate goal of dementia prevention. She leads a randomized controlled trial to enhance physical activity in older adults with a family history of Alzheimer鈥檚 disease that is jointly funded by the NIH and a 2023 Alzheimer Society Research Program New Investigator Award. Dr. Geddes is the recipient of the 2024 Brain Canada Future Leaders Award.
Dr. Geddes obtained an MD at the University of British Columbia, before completing a residency in adult neurology at 秀色直播. She completed a CIHR-funded postdoctoral research fellowship at the McGovern Institute for Brain Research at the Massachusetts Institute of Technology supervised by John Gabrieli.听Dr. Geddes obtained subspecialty UCSN clinical fellowship training in behavioural neurology and neuropsychiatry at Harvard where she then joined the faculty in 2017, before returning to 秀色直播 in 2019. Dr. Geddes鈥� research program was recognized with a Career Development Award from the American Neuropsychiatric Association and appointment as a Montreal Neurological Institute Killam听Scholar. Her research program is funded by the National Institute of Aging, the Canadian Institutes of Health Research, National Sciences and Engineering Research Council of Canada, Healthy Brains Healthy Lives, Fonds de Recherche du Qu茅bec - Sant茅, Brain Canada Foundation and the Alzheimer Society Research Program.
Preprints:
Walker C, Barnoin G, Bennett M, the PREVENT-AD Research Group, Villeneuve S, Geddes MR (2026). The neural basis of prosocial effort-based decision-making in older adults at risk for Alzheimer鈥檚 disease. Medrxiv.
Tremblay SA, Tulsi J, Yang D, Alsibai Z, McDonald I, Aladeeb R, Novielli A, Wong M, Freitas JG, Dhir V, Rajah MN, Godard-Sebillotte C, Altuntur S, Karunananthan S, Geddes MR (2026). Review of current research practices in social and structural determinants of health data collection across Canadian longitudinal studies of aging and dementia. SSRN.
Dhir V, Sarmiento I, McDonald I, Ge虂linas Faucher M, Tremblay SA, Mark J. Yaffe MJ, Andersson A, Geddes MR (2026). Gender-Related Facilitators and Barriers to Participation in Research on Aging using Fuzzy Cognitive Mapping.
Clinical Decision-Making Tools and Clinical Guidance:
Geddes, M. R., O鈥機onnell, M. E., Fisk, J. D., Gauthier, S., Camicioli, R., Ismail, Z., & Covid-19, for the A. S. of C. T. F. on D. C. B. P. for. (2020). Remote cognitive and behavioral assessment: Report of the Alzheimer Society of Canada Task Force on dementia care best practices for COVID-19. Alzheimer鈥檚 & Dementia: Diagnosis, Assessment & Disease Monitoring, 12(1), e12111.
Remote Cognitive Assessment Readiness Tool in partnership with the Canadian Consortium on Neurodegeneration in Aging: (2025)
Selected Publications:
Rajah NM, Dixon Epstein Stern Y, and the Brain Resilience and Diversity in Aging and Dementia Collaboratory (2026). Brain resilience and diversity in aging and dementia. Nature Reviews Neuroscience.
Mohammediyan B, Baril A, Fajardo-Valdez A, St-Onge F, Carrier J, Geddes MR, Ducharme S, Montembeault M, Soucy JP, Breitner JC, Poirier J, Villeneuve S (2026). Longitudinal association between sleep and Alzheimer pathology. Accepted, Alzheimer鈥檚 & Dementia.
Thovinakere N, Ghosh S, Iturria-Medina Y, Geddes MR (2025). Social determinants of health and functional brain connectivity predict long-term physical activity adherence after a new cardiovascular diagnosis. Proceedings of the National Academy of Sciences Nexus. Vol 4, Issue 10, pgaf304,
Walker CS, Noriega de la Colina A, Li L, Boulanger C, Thovinakere N, Barnoin G, Bennett M, Caplan J, C么t茅 L, Elbaz S, Fock Ka Bao S, Kara R, Lavoie N, Nguyen M, Otaner F, Pallett-Wiesel H, Johanie Pich茅 J, Powers A, Ricciardelli S, Williams K, D茅ry D, Tremblay-Mercier J, The PREVENT-AD Research Group, Poirier J, Villeneuve S, Kramer AF, Geddes MR (2025). Protocol for an intergenerational intervention to enhance physical activity engagement in older adults at risk for Alzheimer鈥檚 disease. The Journal of Prevention of Alzheimer鈥檚 Disease.
Friedman NHM, Hallot S, Itzhak I, Desmarais P, Henri-Bhargava A, Pettersen J, Lee L, Fisk JD, Camicioli R, McLaughlin P, Khanassov V, Chertkow H, Freedman M, O鈥機onnell ME, Geddes MR (2025). Red flags for remote cognitive assessment: An expert consensus study using the Delphi method on behalf of the Canadian Consortium on Neurodegeneration in Aging. The Journal of Alzheimer鈥檚 Disease. 106(2):527-536.
Babulal GM, Geddes MR, Germine LT (2025). From Algorithms to Zero-Shot Learning: How Artificial Intelligence Is Redefining Gerontological Research. The Journals of Gerontology: Series B. 80(8).
Villeneuve S, Poirier J, Breitner JCS, Tremblay-Mercier J, Remz J, Raoult JM, Yakoub Y, Gallego-Rudolf J, Qiu T, Fajardo Valdez A, Mohammediyan B, Javanray M, Metz A, Sanami S, Rudolf Wearn A, Pastor-Bernier A, Edde M, Gonneaud J, Strikwerda-Brown C, Leppert IR, Tardif CL, Gauthier CJ, Descoteaux M, Dadar M, Vachon-Presseau E, Baril AA, Ducharme S, Maxime Montembeault M, Geddes MR, Soucy JP, Rajah N, Laforce R, Bocti C, Davatzikos C, Bellec P, Rosa-Neto P, Baillet S, Evans AC, Collins DL, Chakravarty MM, Blennow K, Zetterberg H, Spreng RN, Pichet Binette A, & the PREVENT-AD Research Group (2025). The PREVENT-AD cohort: accelerating Alzheimer鈥檚 disease research and treatment in Canada and beyond. Alzheimer's & Dementia. 21:e70653
Yakoub Y, Gonzalez-Ortiz F, Ashton NJ, Dery C, Strikwerda-Brown C, St-Onge FF, Ourry V, Scholl M, Geddes MR, Ducharme S, Montembeault M, Rosa-Neto P, Soucy JP, Breitner JCS, Zetterberg H, Blennow K, Poirier J, Villeneuve S, PREVENT-AD Research Group (2025). Plasma p-tau217 identifies cognitive normal older adults who will develop cognitive impairment in a 10-year window. Alzheimer鈥檚 & Dementia DOI: 10.1002/alz.14537
Walker CS, Li L, Baracchini G, Tremblay-Mercier J, Villeneuve S, Spreng RN, The PREVENT-AD Research Group, Geddes MR (2024). Neurobehavioral mechanisms influencing the association between generativity, the desire to promote well-being of younger generations, and purpose in life in older adults at risk for Alzheimer鈥� disease. The Journals of Gerontology: Series B, Volume 79, Issue 6, June 2024, gbae060,
Ai M, Morris TP,听Noriega de la Colina A, Thovinakere N, Tremblay-Mercier J, Villeneuve S, Whitfield-Gabrieli, Kramer AF, Geddes MR (2024). Midlife physical activity engagement is associated with later-life cognition and brain health.听Neurobiology of Aging, 134, 146-159.听
Thovinakere, N., Ai, M., Noriega de la Colina, A., Walker, C., Baracchini, G., Tremblay-Mercier, J., Villeneuve, S., Spreng, N., & Geddes, M. (2024). Ventromedial Frontoinsular Connectivity is Associated with Long-term Smoking Behavior Change in Aging.听Imaging Neuroscience,听2.听
Walker, C. S., Li, L., Baracchini, G., Tremblay-Mercier, J., Spreng, R. N., The PREVENT-AD Research Group, & Geddes, M. R. (2024). Neurobehavioral mechanisms influencing the association between generativity, the desire to promote well-being of younger generations, and purpose in life in older adults at risk for Alzheimer鈥檚 disease.听The Journals of Gerontology: Series B,听79(6), gbae060.听
Noriega de la Colina, A., Morris, T. P., Kramer, A. F., Kaushal, N., & Geddes, M. R. (2024). Your move: A precision medicine framework for physical activity in aging.听Npj Aging,听10(1), 16.听
Ai M, Morris TP, Zhang J,听Noriega de la Colina A, Tremblay-Mercier J, Villeneuve S, Whitfield-Gabrieli, Kramer AF, Geddes MR (2023). Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer鈥檚 disease.听Scientific Reports. 13, 7487.听
Friedman NHM, Itzhak I, Desmarais P, Henri-Bhargava A, Pettersen J, Lee L, Fisk JD, Camicioli R, McLaughlin P, Khanassov V, Chertkow H, Freedman M, O鈥機onnell ME, Geddes MR (2023). Remote Cognitive Assessment Readiness Tool for the Canadian Consortium on Neurodegeneration in Aging.听
Geddes MR, Fisk JD, Camicioli R, Ismail Z, O鈥機onnell ME., C. Munro Cullum (2021). Remote Cognitive Assessment: Guiding Principles and Future Directions. World Alzheimer鈥檚 Report 2021: Journey through the diagnosis of dementia. London, England: Alzheimer's Disease International.听
Ai M,听Morris TP,听Ordway C,听Quino帽ez E, D鈥橝gostino F,听Noriega de la Colina A, Whitfield-Gabrieli S, Hillman CH, Pindus DM, Kramer AF, Geddes MR (2021). The daily activity study of health (DASH): A pilot randomized controlled trial to enhance motivation and physical activity in sedentary older adults.听Contemporary Clinical Trials. 106, 106405.听听
Geddes, M. R., O鈥機onnell, M. E., Fisk, J. D., Gauthier, S., Camicioli, R., Ismail, Z., & Covid-19, for the A. S. of C. T. F. on D. C. B. P. for. (2020). Remote cognitive and behavioral assessment: Report of the Alzheimer Society of Canada Task Force on dementia care best practices for COVID-19.听Alzheimer鈥檚 & Dementia: Diagnosis, Assessment & Disease Monitoring,听12(1), e12111.听
Geddes, M. R., Mattfeld, A. T., Angeles, C. de los, Keshavan, A., & Gabrieli, J. D. E. (2018). Human aging reduces the neurobehavioral influence of motivation on episodic memory.听NeuroImage,听171, 296鈥�310.听
Arnold Anteraper, S., Guell, X., Whitfield-Gabrieli, S., Triantafyllou, C., Mattfeld, A. T., Gabrieli, J. D., & Geddes, M. R. (2018). Resting-state functional connectivity of the subthalamic nucleus to limbic, associative, and motor networks.听Brain Connectivity,听8(1), 22鈥�32.听
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