BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250629T022706EDT-7117v556GA@132.216.98.100 DTSTAMP:20250629T062706Z DESCRIPTION:The Seminars in Epidemiology organized by the Department of Epi demiology\, Biostatistics and Occupational Health at the ɫֱ School of Population and Global Health is a self-approved Group Learning Activity (S ection 1) as defined by the maintenance of certification program of the Ro yal College of Physicians and Surgeons of Canada. Physicians requiring acc reditation\, please complete the Evaluation Form and send to admincoord.eb oh [at] mcgill.ca\n\nAnita Koushik\, PhD\n\nDirector\, Division of Cancer Epidemiology\n Professor\, Department of Oncology\, ɫֱ\n\nWH EN: Monday\, November 18\, 2024\, from 4 to 5 p.m.\n WHERE: Hybrid| 2001 Mc Gill College\, Rm 1140 | Zoom \n NOTE: Anita Koushik will be presenting in- person \n\nAbstract\n\nCancer has long been known to be a disease of aging . Indeed\, the highest proportions of new diagnoses occur in those between the ages of 65 and 74 years. Related to this is that the induction period of cancer development with most causes is long\, likely in decades. Thus\ , to optimize research resources in past cancer prevention studies\, resea rchers have generally measured candidate lifestyle and behavioural risk fa ctors in middle-to-older-aged adults. However\, there is increasing recogn ition that exposures even earlier in life may influence future cancer risk . For instance\, early menarche is associated with increased breast cancer risk\, and human papillomavirus infection\, usually first acquired during teenage/early adult years\, is a necessary cause of cervical cancer diagn osed decades later. About 4 in 10 cancers cases can be prevented with curr ent knowledge of lifestyle and environmental factors\, but this number cou ld be increased with a better understanding of the role of timing of expos ures.\n\nOne cancer of critical importance to women’s health is ovarian ca ncer. It has the highest case-fatality of all gynecologic cancers and will be diagnosed in 1 in 71 Canadian women during their lifetime. Primary pre vention efforts are hampered because the etiology is not well understood. Only increasing parity and oral contraceptive use are established as modif iable factors associated with risk reduction. Interestingly\, both of thes e “exposures” occur relatively early in adulthood. Conversely\, menopausal hormone therapy\, which slightly increases ovarian cancer risk\, is prima rily used later in adulthood (i.e.\, during perimenopause). Different risk factors may thus have different effects on ovarian cancer risk depending on the specific life periods of exposure.\n\nThis presentation will share the results of our research examining modifiable lifestyle factors\, namel y vitamin D\, body fatness and physical activity\, in relation to ovarian cancer risk with a formal consideration of timing of exposure.\n\nLearning Objectives\n\nAt the end of this talk\, attendees will:\n\n\n Understand t he gaps in knowledge related to cancer prevention efforts and the potentia l importance of timing of exposure\;\n Become familiar with the utility of the life course approach to epidemiologic research when studying cancer et iology\;\n Appreciate the application of the weighted cumulative exposure ( WCE) method and the Bayesian relevant life course exposure model (BRLM).\n \n\nSpeaker Bio\n\nAnita Koushik is a Professor in the Gerald Bronfman Dep artment of Oncology\, Principal Scientist at St. Mary's Research Centre an d inaugural holder of the ɫֱ Chair in Community Cancer Care at St. Mary’s. Since August 2024\, she is Director of the Division of Can cer Epidemiology. Her research program aims to increase our understanding of the etiology of cancer in order to improve primary prevention and risk assessment efforts. She also conducts research on the identification of mo difiable factors that can improve prognosis and quality of life of cancer survivors.\n DTSTART:20241118T210000Z DTEND:20241118T220000Z SUMMARY:Lifestyle Factors and Cancer Prevention: Understanding the Role of Exposure Timing URL:/epi-biostat-occh/channels/event/lifestyle-factors -and-cancer-prevention-understanding-role-exposure-timing-360969 END:VEVENT END:VCALENDAR